I had a decent time at all three of these breweries in the downtown area -> Tenaya Creek, Hop Nuts and Banger. Banger is great for people watching - sit outside and watch the "show" on Fremont Street. Atomic Liquors has a damn good taplist ... plus it's the oldest bar in Vegas, which is kinda cool. Tacos & Beer has an excellent taplist as well. Beer Garden is owned by the "evil" Budweiser, but in terms of space, it rocks - overlooks The Strip.
When looking for a great tap list and fun wait staff, either of the two Aces & Ales is always a good time.
Public House at the Venetian isn't bad as well as the PUB at Monte Carlo. I usually stay at the Vdara so I usually stock my fridge. I enjoyed watching the Bellagio Fountains drinking Cuivre straight out of the bottle last trip.